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Helicobacter pylori is one of the most common pathogens entering the digestive tract through the oral cavity, and it is the main pathogenic factor leading to chronic gastritis and peptic ulcer.1,2 The detection of urease in human tartar provides the basis for the auxiliary diagnosis of the Helicobacter pylori infection. At present, the commonly used clinical detection methods are gastric mucosa biopsy and urea breath test, etc.3 Tests for urease are specific for H. pylori because mammalian cells do not produce urease and very few microorganisms survive in the stomach, except for H. pylori.